Por otra parte, en la segunda alícuota se realizó el proteinograma y se . de alfa- glicoproteína ácida (mg/dl) Bandas electroforéticas () () Albúmina .. de desnutrición se puede interpretar como una disminución de la síntesis. ¿Qué estudios solicitaría? EXAMEN FÍSICO ateneo de neurología. Motivo de consulta. Paciente mujer de 22 años de edad. Diciembre Puede haber alteraciones que i m p i d a n su n o r m a l interpretación (bloqueo h i – • P r o t e i n o g r a m a p o r electroforesis de L C R: e n búsqueda de bandas Bibliografía • Adams RD. proteinograma t r a s t o r n o s s e n s i t i v o s.

Author: Kazill Juk
Country: Algeria
Language: English (Spanish)
Genre: Politics
Published (Last): 14 June 2006
Pages: 274
PDF File Size: 2.33 Mb
ePub File Size: 4.59 Mb
ISBN: 888-6-95432-346-5
Downloads: 27714
Price: Free* [*Free Regsitration Required]
Uploader: Salkree

Statistical analysis using least squares regression indicated excellent linearity for gefitinib in electrofordtico mentioned concentration ranges. If necessary, the use of intestinal transit compartments was explored by adding compartments until model fit did not improve significantly. Biliary excretion of etoposide did not seem to change in undernourishment status Bottom panels represent ka values for norm-nourished left and undernourished right rats for each perfused solution and intestinal segment proximal: InCusak et al.

Departamento de Farmacia y Tecnología Farmacéutica y Parasitología

Regarding gefitinib, its antiproliferative activity in preclinical studies, alone or in combination with cytotoxic drugs, was investigated in human ovarian, breast, and colon cancer cell lines, which express EGFR and transforming growth factor alpha.

This pharmacokinetic behaviour was evidenced both in proximal and distal intestine: Each rat received 1mL of the corresponding drug preparation. Models describing pharmacokinetics in mammals in general have a central compartment representing plasma and in some occasions with one or more peripheral compartments linked to the central compartment by rate constants Figure 1. Secondly, traditional cytotoxic chemotherapeutic agents are administered according to patient s body surface area, whereas TKIs are orally given on a daily basis at fixed doses.


ateneo de neurología by Debora Nadur on Prezi

The number of samples processed in a hour period was never higher than 10, in order to prevent an acute decrease of haematocrit. To use this website, you must agree to our Privacy Policyincluding cookie policy. On the other side, for Weibull absorption models, dichotomous covariates presence. Plots of CWRES against time should exhibit random scattering around the zero reference line and can be used to further assess model adequacy.

The mechanism behind this behaviour might be a reduction in the microvilli in the small intestine of undernourished rats. Minimum objective function value; bold: A major clinical implication of such reduction is interpretcaion the concentration of the lipid-soluble drug would increase at the target tissues, thus increasing its pharmacodynamics PD actions Model parameter estimates and bootstrap results of proximal and distal intestine absorption models are shown in Tablesrespectively.

In vivo pharmacokinetic studies evaluated LADME processes liberation, absorption, distribution, metabolism and excretion. The extrapolation of results obtained in rats up to human patients was performed through simulations. Plots involving the weighted residuals WRESi. Figure Visual predictive check plot for gefitinib after intravenous administration. Evaluation of the interaction in undernutrition situations through population pharmacokinetic analysis in rats.

The animal model of under-nutrition developed by Merino et al. Molecular PK determinants of erlotinib and gefitinib can play an important role in therapeutic outcomes. Erlotinib and Gefitinib Erlotinib and gefitinib Pharmacokinetic modelling Introduction to pharmacokinetic modelling Structural, statistical and covariate models Objectives Materials and Methods Study design Assayed drugs Erlotinib Gefitinib Undernutrition protocol Surgical procedures Blood and tissue sampling Intestinal cannulation Jugular cannulation Assay protocols.

  ISO 13936-1 PDF

Effective absorption rate constant was calculated as absorption rate divided by concentration in intestinal lumen. Goodness-of-fit plots for proximal left and distal right intestine erlotinib absorption models. Nevertheless, this methodology is not a screening tool but an assessment tool, and the required information for its use makes it difficult to implement in the clinical setting. Stacy Evans KudoZ activity Questions: The PK properties of macromolecules differ markedly from those of non-antibody-type drugs, and these properties can have important clinical implications.

Análisis de globulinas: Información en MedlinePlus sobre pruebas de laboratorio

Additionally, data were evaluated using mechanistic models considering linear and non-linear kinetics. Given that models obtained through a mechanistic approach were not completely satisfactory, the Weibull equation was evaluated. It has been previously described that a dynamic equilibrium between intestinal lumen and enterocyte is achieved in the first five elevtroforetico since the start of the perfusion. This drug is primarily excreted by the kidneys and its elimination halflife was evidenced to be more prolonged in the malnourished than wellnourished eldctroforetico