La polineuropatía desmielinizante inflamatoria crónica es un trastorno neurológico caracterizado por debilidad progresiva y función sensorial alterada en las. Disease definition. Subacute inflammatory demyelinating polyneuropathy (SIDP) is a subacute progressive symmetric sensorial and/or motor disorder. Disease definition. Polyneuropathy associated with IgM monoclonal gammapathy (MG) with anti-MAG (myelin-associated-glycoprotein) activity is a.

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Polyneuropathy associated with IgM monoclonal gammapathy MG with anti-MAG myelin-associated-glycoprotein activity is a demyelinating polyneuropathy characterized clinically by sensory ataxia, tremor, paresthesia, and impaired gait.

She was treated with 3g IV methylprednisolone and symptoms resolved completely. The association of MG to demyelinating disease is rare and has been described before.

Demyelinating disease in patients with myasthenia gravis

Prednisone was switched to azathioprine due to hypertension, but symptoms only resolved when cyclosporine was started. Summary and related texts. Two of our patients have undergone thymectomy and only one presented positive ANA patient 3 ; interestingly, this was the only one that evolved to a recurrent DD. Patients with MG can present other autoimmune diseases in association, commonly hypo or hyperthyroidism. Received 3 August desmielinisantes, received in final form 14 November Symptoms resolved completely and his visual acuity returned to normal 2 months later.

Multiple sclerosis and myasthenia gravis: For all other comments, please send your remarks via contact us. We found three patients with MG that developed DD during follow-up; their clinical, electrophysiological and autoantibodies status are described in Tables 1 and 2.

Rare cases of spontaneous doenzs have also been reported. Patients that presented with symptoms suggesting DD were selected for description. In conclusion, demyelinating diseases are rare among patients with MG and may be part of an autoimmune syndrome spectra or genetic predisposition to autoimmunity.


Additional information Further information on this disease Classification s 1 Gene s 0 Desmielinuzantes website s 0. Recurrent transverse myelitis, myasthenia gravis, and autoantibodies. Only comments seeking to improve the quality and accuracy of information on the Orphanet website are accepted.

Additional information Demielinizantes information on this disease Classification s 1 Gene s 0 Clinical signs and symptoms Other website s 0. Although all our patients achieved a good control of myasthenia symptoms, we could not determine the influence of developing DD on MG control due to the small number of patients in this series. Health care resources for this disease Expert centres Diagnostic tests 0 Patient organisations 6 Orphan drug s 0.

Cyclosporine dose was raised and deflazacort introduced for symptomatic treatment of ptosis. Recently, two reports have focused on this association.

Fundoscopic examination revealed a swollen disc on vesmielinizantes left eye. Professionals Clinical practice guidelines Deutsch Cytoalbuminologic dissociation in CSF is characteristic, pointing to nerve root involvement. In addition, supportive criteria include raised CSF proteins and segmental and multifocal demyelination in nerve biopsy in clinically suspected SIDP cases in which electrophysiological proof of demyelination is absent.

He was initially treated with prednisone and pyridostigmine with mild response to treatment.

Doenças metabólicas/dis e desmielinizantes

Occasionally, CSF studies reveal mild lymphocytic pleocytosis and elevated desmielinizanes globulins. Optic neuritis, transverse myelitis, and anti-DNA antibodies nine years after thymectomy for myasthenia gravis.

Anti-thyroid antibodies were present anti-thyroid peroxidase and anti-tireoglobulinbut she never developed thyroid disease symptoms. Weinshenker BG, Jacob A. Acta Neurol Scand ; Patients with MG commonly have thyroid disease and can present with nonspecific immune system abnormalities, such as positive auto antibodies and alopecia areata Only comments seeking to improve the quality and accuracy of information on the Orphanet website are accepted.


We report on three Brazilian patients with MG that presented distinct demyelinating diseases, two monophasic and one recurrent neuromyelitis optica, several years after the diagnosis of MG, and discuss their clinical courses. Two of them presented a monophasic course patients 1 and 2one evolved to recurrent neuromyelitis optica patient 3.

Patient 2 had intermittent diplopia since the age of 27 and was further diagnosed with ocular myasthenia. Neuromyelitis optica associated with myasthenia gravis: Some authors state that this association may not happen by chance, as the incidence of DD in patients with MG is much higher than expected in the general population 6,15and both may be part of multiple autoimmune syndromes or genetic predisposition to autoimmunity 5.

Diagnosis is based on clinical and electrophysiological findings. The authors suggest that the association might be caused by subclinical systemic lupus erythematosus in three of them due to the presence of antinuclear antibodies, including both cases with recurrent DD, although this has desmieelinizantes contested due to the fact that two of their patients could actually have NMO Subacute inflammatory demyelinating polyradiculoneuropathy Prevalence: Myasthenia gravis accompanied by alopecia areata: Only comments written in English can be processed.

The desmielinizsntes contained in this web site are presented for information purposes only. She underwent thymectomy one year later and evolved asymptomatic on pyridostigmine treatment, thymus pathology disclosed lymphoid hyperplasia. This patient resembles those reported by Kister et al. J Allergy Clin Immunol coenas Diagnostic methods Diagnosis is based on clinical and electrophysiological findings.